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  Improving performance of simulated moving bed chromatography by fractionation and feed-back of outlet streams

Keßler, L. C., & Seidel-Morgenstern, A. (2008). Improving performance of simulated moving bed chromatography by fractionation and feed-back of outlet streams. Journal of Chromatography A, 1207(1-2), 55-71. doi:10.1016/j.chroma.2008.08.022.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-967C-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B5A3-E
Genre: Journal Article

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 Creators:
Keßler, L. C.1, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Simulated moving bed; Chromatography; Recycle; Fractionation; Feed-back; Partial Discard; FF-SMB
 Abstract: Simulated moving bed (SMB) chromatography is an important technique for the continuous separation of valuable products. Recently suggested process modifications have shown the potential for further improvement. In this work, a concept is presented that combines non-permanent product withdrawal at one or both outlet ports (leading periodically to a “product” and a “non-product” fraction) with an internal recycle and re-feeding of the “non-product” fraction in alternation to the original feed mixture. Using simulation studies for linear and non-linear isotherms, it was shown that in terms of process performance and product recovery, this fractionation and feed-back approach (FF-SMB) is superior to both the conventional SMB process as well as to a previously reported fractionation and discard strategy. Copyright © 2008 Elsevier B.V. All rights reserved. [accessed October 28, 2008]

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Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 378902
Other: 20/08
DOI: 10.1016/j.chroma.2008.08.022
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1207 (1-2) Sequence Number: - Start / End Page: 55 - 71 Identifier: ISSN: 0021-9673
CoNE: /journals/resource/954925527837_1