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Simulated moving bed; Chromatography; Recycle; Fractionation; Feed-back; Partial Discard; FF-SMB
Abstract:
Simulated moving bed (SMB) chromatography is an important technique for the continuous separation of valuable products. Recently suggested process modifications have shown the potential for further improvement. In this work, a concept is presented that combines non-permanent product withdrawal at one or both outlet ports (leading periodically to a “product” and a “non-product” fraction) with an internal recycle and re-feeding of the “non-product” fraction in alternation to the original feed mixture. Using simulation studies for linear and non-linear isotherms, it was shown that in terms of process performance and product recovery, this fractionation and feed-back approach (FF-SMB) is superior to both the conventional SMB process as well as to a previously reported fractionation and discard strategy.
Copyright © 2008 Elsevier B.V. All rights reserved.
[accessed October 28, 2008]
