English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Subnetwork Analysis for Multistationarity in Mass Action Kinectics

Flockerzi, D., & Conradi, C. (2008). Subnetwork Analysis for Multistationarity in Mass Action Kinectics. Journal of Physics: Conference Series, 138, 012006. doi:10.1088/1742-6596/138/1/012006.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9684-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0028-1402-7
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Flockerzi, D.1, Author              
Conradi, C.1, Author              
Affiliations:
1Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738154              

Content

show
hide
Free keywords: -
 Abstract: Since quantitative knowledge of the complex (bio)chemical reaction networks is often very limited, formal methods that connect network structure and dynamic behavior are needed in mathematical modeling and analysis. Feinberg's Chemical Reaction Network Theory allows for the classification of the potential network behavior, for instance, with respect to the existence of multiple steady states, but is computationally limited to small systems. Here, we show that by analyzing subnetworks associated to stoichiometric generators, the applicability of the theory can be extended to more complex networks. Moreover, based on mild conditions regarding multiststionarity of such subnetworks, we present an algorithm which establishes multistationarity in the overall network. For example-networks inspired by cell cycle control in budding yeast, the approach allows for identification of key mechanisms for multistationarity, for model discrimination and for robustness analysis. The present paper continues and extends our work that has appeared in PNAS (cf. [6]). © 2013 IOP Publishing [accessed 2013 June 14th]

Details

show
hide
Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1088/1742-6596/138/1/012006
eDoc: 379343
Other: 40/08
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Physics: Conference Series
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 138 Sequence Number: - Start / End Page: 012006 Identifier: -