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  Spatial Desynchronization of Glycolytic Waves as Revealed by Karhunen−Loeve Analysis

Bagyan, S., Mair, T., Suchorski, Y., Hauser, M. J. B., & Straube, R. (2008). Spatial Desynchronization of Glycolytic Waves as Revealed by Karhunen−Loeve Analysis. Journal of Physical Chemistry B, 112(45), 14334-14341. doi:10.1021/jp805087m.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9694-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F714-F
Genre: Journal Article

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 Creators:
Bagyan, S.1, Author
Mair, T.1, Author
Suchorski, Y.2, Author
Hauser, M. J. B.1, Author
Straube, R.3, Author              
Affiliations:
1Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
2Vienna University of Technology, ou_persistent22              
3Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              

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 Abstract: The dynamics of glycolytic waves in a yeast extract have been investigated in an open spatial reactor. At low protein contents in the extract, we find a transition from inwardly moving target patterns at the beginning of the experiment to outwardly moving spiral- or circular-shaped waves at later stages. These two phases are separated by a transition phase of more complex spatiotemporal dynamics. We have analyzed the pattern dynamics in these three intervals at different spatial scales by means of a Karhunen−Loève (KL) decomposition. During the initial phase of the experiment, the observed patterns are sufficiently described by the two dominant KL modes independently of the spatial scale. However, during the last stage of the experiment, at least 6 KL modes are needed to account for the observed patterns at spatial scales larger than 3 mm, while for smaller scales, 2 KL modes are still sufficient. This indicates that in the course of the experiment, the local glycolytic oscillators become desynchronized at spatial scales larger than 3 mm. Possible reasons for the desynchronization of the glycolytic waves are discussed. Copyright © 2013 American Chemical Society [accessed 2013 June 14th]

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Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1021/jp805087m
eDoc: 379991
Other: 21/08
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Title: Journal of Physical Chemistry B
Source Genre: Journal
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Pages: - Volume / Issue: 112 (45) Sequence Number: - Start / End Page: 14334 - 14341 Identifier: -