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  Effects of a Strongly Adsorbed Additive on Process Performance in Chiral Preparative Chromatography

Forssen, P., Arnell, R., Kaspereit, M., Seidel-Morgenstern, A., & Fornstedt, T. (2008). Effects of a Strongly Adsorbed Additive on Process Performance in Chiral Preparative Chromatography. Journal of Chromatography A, 1212(1-2), 89-97. doi:10.1016/j.chroma.2008.10.040.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-96B3-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0019-8D53-8
Genre: Journal Article

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 Creators:
Forssen, P.1, Author
Arnell, R.2, Author
Kaspereit, Malte3, Author              
Seidel-Morgenstern, A.4, 5, Author              
Fornstedt, T.1, Author
Affiliations:
1Department of Physical and Analytical Chemistry, Uppsala, Sweden, ou_persistent22              
2AstraZeneca Process R&D, Södertälje, Sweden, ou_persistent22              
3Process Synthesis and Process Dynamics, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738153              
4Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
5Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Band shape tuning; Unusual band shapes; adsorption data; additive; cycle time; numerical optimization; productivity; yield
 Abstract: The shapes of elution profiles are often significantly influenced by the presence of strongly adsorbed additives in the mobile phase. This aspect needs to be considered in quantitative optimization of preparative chromatography. The theoretical study carried out here is based on available thermodynamic information for the enantiomers of three b-blockers, alprenolol, propranolol, and atenolol, on a teicoplanin chiral stationary phase (Chirobiotic T) using methanol/acetonitrile as the mobile phase and acetic acid/triethylamine as the additive. The properties of this strong additive made it possible to tune the binary bands in any combination of the following apparent band shapes: anti-Langmuir/anti-Langmuir, anti-Langmuir/Langmuir and Langmuir/Langmuir. Optimization of the productivity and yield, when performing repetitive batch injections, was investigated using the equilibrium dispersive model. We show that it is important to consider the invisible additive perturbation peak when defining the cycle time and therefore a model-based optimization needs to take this into account. Furthermore, both productivity and yield could be improved for the two unusual shape combinations in comparison to the traditional Langmuir/Langmuir case. Copyright © 2008 Elsevier B.V. All rights reserved. [accessed October 28, 2008]

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Language(s): eng - English
 Dates: 2008
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 367092
DOI: 10.1016/j.chroma.2008.10.040
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1212 (1-2) Sequence Number: - Start / End Page: 89 - 97 Identifier: ISSN: 0021-9673
CoNE: /journals/resource/954925527837_1