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  Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor

Genzel, Y., Fischer, M., Olmer, R. M., Schäfer, B., Best, C., König, S., et al. (2007). Serum-free influenza vaccine production with MDCK cells in wave-bioreactor and 5L-stirred tank bioreactor. In R. Smith (Ed.), Cell Technology for Cell Products: Proceedings of the 19th ESACT Meeting (pp. 563-565). Dordrecht, The Netherlands: Springer.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-986D-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-6A8D-D
Genre: Conference Paper

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 Creators:
Genzel, Y.1, Author              
Fischer, Marlies1, 2, Author              
Olmer, R. M.1, 3, Author              
Schäfer, B.1, Author              
Best, C.4, Author
König, S.1, Author              
Hundt, B.1, Author              
Reichl, U.1, 5, Author              
Affiliations:
1Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140              
2Universität Stuttgart, Lehrstuhl für Bioverfahrenstechnik, Stuttgart, Germany , ou_persistent22              
3Universität Bielefeld, Lehrstuhl für Zellkulturtechnik, persistent:22              
4Lehrstuhl für Bioverfahrenstechnik, Universität Stuttgart, Stuttgart, Germany.Lehrstuhl für Zellkulturtechnik, Universität Bielefeld, Bielefeld, Germany.Lehrstuhl für Bioprozesstechnik, Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany., ou_persistent22              
5Otto-von-Guericke-Universität Magdeburg, ou_1738156              

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 Abstract: A serum-free process for influenza virus vaccine production (equine and human) in roller bottles and microcarrier systems in 5L-stirred tank and 2L-wave bioreactor (Cytodex 1) is described. MDCK cells were adapted from growth in serum containing GMEM medium to serum-free Ex-Cell MDCK medium. Virus titers of 2.0-2.9 log HA units/ 100 µL were obtained. Omission of the medium exchange before infection has clearly simplified the process. © Springer, Part of Springer Science+Business Media [accessed 2013 September 9th]

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Language(s): eng - English
 Dates: 2007
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 245286
DOI: 10.1007/978-1-4020-5476-1_97
 Degree: -

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Title: 19th ESACT Meeting
Place of Event: Harrogate, UK
Start-/End Date: 2005-06-05 - 2005-06-08

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Title: Cell Technology for Cell Products : Proceedings of the 19th ESACT Meeting
Source Genre: Proceedings
 Creator(s):
Smith, R., Editor
Affiliations:
-
Publ. Info: Dordrecht, The Netherlands : Springer
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 563 - 565 Identifier: -