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  Conceptual design & feasibility study of combining continuous chromatography and crystallization for stereoisomer separations

Gedicke, K., Kaspereit, M., Beckmann, W., Budde, U., Lorenz, H., & Seidel-Morgenstern, A. (2007). Conceptual design & feasibility study of combining continuous chromatography and crystallization for stereoisomer separations. Chemical Engineering Research and Design, 85(7), 928-936. doi:10.1205/cherd06224.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-98B8-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-C01D-0
Genre: Journal Article

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 Creators:
Gedicke, K.1, Author              
Kaspereit, Malte2, Author              
Beckmann, W.3, Author
Budde, U.3, Author
Lorenz, H.1, Author              
Seidel-Morgenstern, A.1, 4, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Process Synthesis and Process Dynamics, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738153              
3Schering AG, Verfahrenstechnik, Berlin, Germany, ou_persistent22              
4Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: process combination; SMB-chromatography; crystallisation; shortcut method; enantioseparation
 Abstract: The separation of stereoisomers - diastereoisomers and enantiomers - constitutes an important class of problems in life science applications, namely in drug manufacture. Chromatography is often the method of choice to perform this task. To decrease the typically high investment and operational costs of the chromatographic separation, it can be beneficial to combine this process with a selective crystallisation step. This work investigates such process combination of Simulated Moving Bed chromatography and crystallisation from solution. A short-cut method, based on only a few fundamental experimental parameters, is applied to evaluate the process combination for one enantiomeric and one epimeric system. While the enantiomeric system is characterised by a simple conglomerate phase diagram, the epimeric system shows some characteristic properties, like incorporation of the counter epimer and an additional impurity into the crystal lattice of the product epimer, that have to be accounted for by more detailed investigations. Copyright © 2007 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. [accessed February 8th 2013]

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Language(s): eng - English
 Dates: 2007
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 298173
DOI: 10.1205/cherd06224
 Degree: -

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Title: Chemical Engineering Research and Design
Source Genre: Journal
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Publ. Info: Rugby [England] : Elsevier
Pages: - Volume / Issue: 85 (7) Sequence Number: - Start / End Page: 928 - 936 Identifier: ISSN: 0263-8762
CoNE: https://pure.mpg.de/cone/journals/resource/954925267290