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Free keywords:
eremomycin; chiral stationary phase; methionine; simulated moving bed; adsorption isotherms; stability
Abstract:
Recently a new chiral stationary phase (CSP) was introduced, based on the immobilization of the macrocyclic glycopeptide eremomycin to epoxy-activated silica. The application of this new CSP to preparative enantioseparation using simulated moving bed chromatography (SMB) will be presented. In such delicate continuous separation processes, besides selectivity, the long-term stability of the applied stationary phases is of importance. Column to column fluctuations of the bed homogeneity and long-term stability of the preparative stationary phase was satisfactory according to the results of perturbation experiments performed before and after long-term SMB runs.
Copyright © 2007 Elsevier B.V. All rights reserved. [accessed 2013 November 26th]
