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  Vaccine production - state of the art and future needs in upstream processing

Genzel, Y., & Reichl, U. (2007). Vaccine production - state of the art and future needs in upstream processing. In R. Pörtner (Ed.), Animal Cell Biotechnology: Methods and Protocols (pp. 457-473). Totowa, New Jersey: HUMANA Press Inc.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-98E9-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-78E3-8
Genre: Book Chapter

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 Creators:
Genzel, Y.1, Author              
Reichl, U.1, 2, Author              
Affiliations:
1Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140              
2Otto-von-Guericke-Universität Magdeburg, ou_1738156              

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 Abstract: The production of viral vaccines in animal cell culture can be accomplished with primary, diploid or continuous (transformed) cell lines. Each cell line, each virus type and each vaccine definition requires a specific production and purification process. Media have to be selected as well as the production vessel, production conditions and the type of process. Here, we describe different issues that have to be considered during virus production processes by discussing the influenza virus production in a microcarrier system in detail as an example. The use of serum-containing as well as serum-free media, but also the use of stirred tank bioreactors or wave bioreactors is considered. Copyright © 2008 Springer Science+Business Media, LLC. All rights reserved [accessed 2013 October 29th]

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Language(s): eng - English
 Dates: 2007
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 322129
DOI: 10.1007/978-1-59745-399-8_21
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Title: Animal Cell Biotechnology : Methods and Protocols
Source Genre: Book
 Creator(s):
Pörtner, R., Editor
Affiliations:
-
Publ. Info: Totowa, New Jersey : HUMANA Press Inc.
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 457 - 473 Identifier: ISBN: 978-1-58829-660-3

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Title: Methods in Biotechnology
Source Genre: Series
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Pages: - Volume / Issue: 24 Sequence Number: - Start / End Page: - Identifier: -