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  Characterization and analytical issues on an influenza A virus production process

Genzel, Y., Kalbfuss, B., Ritter, J. B., Schulze-Horsel, J., Rapp, E., Vester, D., et al. (2006). Characterization and analytical issues on an influenza A virus production process. Talk presented at Vaccines: Quality control, scale-up and manufacture. Hamburg, Germany. 2006-12-05 - 2006-12-06.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9961-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-0C7A-5
Genre: Talk

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 Creators:
Genzel, Y.1, Author              
Kalbfuss, B.1, Author              
Ritter, J. B.1, Author              
Schulze-Horsel, J.1, Author              
Rapp, E.2, Author              
Vester, D.1, Author              
Reichl, U.1, 3, Author              
Affiliations:
1Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3Otto-von-Guericke-Universität Magdeburg, ou_1738156              

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 Abstract: Different approaches for a mammalian cell culture based production process for influenza vaccines are currently in development. Each approach needs optimization based on analytical data collected from many small scale experiments. In the presentation results for different cultivation methods (rollerbottles, stirred tank or wave bioreactor microcarrier system) for a production process with adherent MDCK cells are discussed. Analytical data on cell numbers, metabolism, host cell protein level, cell cycle and virus titer are shown.

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Language(s): eng - English
 Dates: 2006
 Publication Status: Not specified
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 293565
 Degree: -

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Title: Vaccines : Quality control, scale-up and manufacture
Place of Event: Hamburg, Germany
Start-/End Date: 2006-12-05 - 2006-12-06
Invited: Yes

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