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  Application of an eremomycin chiral stationary phase for the separation of DL-methionine using simulated moving bed chromatography

Zhang, L., Gedicke, K., Niedbala, S., Antos, D., Staroverov, S. M., & Seidel-Morgenstern, A. (2006). Application of an eremomycin chiral stationary phase for the separation of DL-methionine using simulated moving bed chromatography. Poster presented at SPICA 2006: 11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques, Innsbruck, Austria.

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 Urheber:
Zhang, L.1, Autor           
Gedicke, K.1, Autor           
Niedbala, S.2, Autor
Antos, D.1, 3, Autor           
Staroverov, S. M.2, Autor
Seidel-Morgenstern, A.1, 4, Autor           
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Institut für Verfahrenstechnik, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany Chemical Engineering Department, Rzeszów University of Technology, Al. Powstancow Warszawy 6, 35-959 Rzeszów, Poland Lomonosov State University, Moscow, Russia, ou_persistent22              
3Rzeszow Univ Technol, Rzeszow, Poland, persistent:22              
4Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Zusammenfassung: Preparative chromatography has become an accepted tool in pharmaceutical industry for the production of enantiopure drugs and intermediates. An important reason is the still increasing availability of efficient chiral stationary phases (CSP). Recently, a new CSP of the class of macrocyclic glycopeptides was introduced, based on the immobilization of eremomycin to epoxy-activated silica1. This new phase has been shown to have a good selectivity with regard to amino acids in the analytical concentration range2. The application of this new CSP to preparative enantioseparation using simulated moving bed chromatography (SMB) will be presented. For preparative enantioseparations, besides selectivity, the long term stability of stationary phases is of importance. A critical test for the stability is the application in an SMB-unit, where the stationary phase is subject to high sample concentrations. The separation of the enantiomers of methionine is used as a model system. The mobile phase consists of 20/80v/v Methanol/Water (0.1M NaH2PO4). Competitive adsorption isotherms of D- and L-methionine were measured up to the solubility limit in the mobile phase by means of a perturbation method. Extensive perturbation experiments were performed, in order to test column stability and column to column reproducibility. The obtained adsorption isotherms were validated with breakthrough and overloaded elution experiments. In order to test the stability of the stationary phase small injections were performed before and after the perturbation experiments. 8 columns (0.8x6cm) were used for long term simulated moving bed experiments in a lab scale Prochrom SMB unit (Novasep, France). On the poster the results of the determination of the adsorption isotherms, the evaluation of the stability of the columns and the performed SMB-runs will be presented and discussed. 1 S.M. Staroverov, M.A. Kuznetsov, P.N. Nesterenko, G.G. Vasiarov, G.S. Katrukha, G.B. Fedorova, J. Chromatogr. A 1108 (2006) 263–267 2 K. Petrusevska, M.A. Kuznetsov, K. Gedicke, V. Meshko, S.M. Staroverov, A. Seidel-Morgenstern, J. Sep. Science, accepted

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Sprache(n): eng - English
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 Identifikatoren: eDoc: 283476
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Veranstaltung

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Titel: SPICA 2006 : 11th International Symposium on Preparative and Industrial Chromatography and Allied Techniques
Veranstaltungsort: Innsbruck, Austria
Start-/Enddatum: 2006-10-15 - 2006-10-18

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