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  Coexistence in the Chemostat as a result of metabolic by-products

Heßeler, J., Schmidt, J. K., Reichl, U., & Flockerzi, D. (2006). Coexistence in the Chemostat as a result of metabolic by-products. Journal of mathematical biology, 53(4), 556-584. doi:10.1007/s00285-006-0012-3.

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アイテムのパーマリンク: http://hdl.handle.net/11858/00-001M-0000-0013-9AF7-E 版のパーマリンク: http://hdl.handle.net/11858/00-001M-0000-0014-A148-0
資料種別: 学術論文

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 作成者:
Heßeler, J.1, 著者              
Schmidt, J. K.1, 著者              
Reichl, U.1, 2, 著者              
Flockerzi, D.3, 著者              
所属:
1Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738140              
2Otto-von-Guericke-Universität Magdeburg, ou_1738156              
3Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738154              

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 要旨: Classical chemostat models assume that competition is purely exploitative and mediated via a common, limiting and single resource. However, in laboratory experiments with pathogens related to the genetic disease Cystic Fibrosis, species specific properties of production, inhibition and consumption of a metabolic by-product, acetate, were found. These assumptions were implemented into a mathematical chemostat model which consists of four nonlinear ordinary differential equations describing two species competing for one limiting nutrient in an open system. We derive classical chemostat results and find that our basic model supports the competitive exclusion principle, the bistability of the system as well as stable coexistence. The analytical results are illustrated by numerical simulations performed with experimentally measured parameter values. As a variant of our basic model, mimicking testing of antibiotics for therapeutic treatments in mixed cultures instead of pure ones, we consider the introduction of a lethal inhibitor, which cannot be eliminated by one of the species and is selective for the stronger competitor. We discuss our theoretical results in relation to our experimental model system and find that simulations coincide with the qualitative behavior of the experimental result in the case where the metabolic by-product serves as a second carbon source for one of the species, but not the producer. © Springer, Part of Springer Science+Business Media [accessed 2013 August 16th]

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言語: eng - 英語
 日付: 2006
 出版の状態: 紙媒体で出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: -
 識別子(DOI, ISBNなど): eDoc: 286482
その他: 51/06
DOI: 10.1007/s00285-006-0012-3
 学位: -

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出版物名: Journal of mathematical biology
種別: 学術雑誌
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出版社, 出版地: Heidelberg : Springer
ページ: - 巻号: 53 (4) 通巻号: - 開始・終了ページ: 556 - 584 識別子(ISBN, ISSN, DOIなど): ISSN: 0303-6812
CoNE: /journals/resource/954925511424