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  Application of Preferential Crystallization to Resolve Racemic Compounds in a Hybrid Process

Lorenz, H., Polenske, D., & Seidel-Morgenstern, A. (2006). Application of Preferential Crystallization to Resolve Racemic Compounds in a Hybrid Process. Chirality, 18(10), 828-840. doi:10.1002/chir.20327.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9B03-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B800-2
Genre: Journal Article

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 Creators:
Lorenz, H.1, Author              
Polenske, D.1, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: chiral resolution; resolution by entrainment; hybrid process; mandelic acid; compound forming chiral systems; online monitoring; crystallization trajectory
 Abstract: The application of preferential crystallization is at present limited to conglomerate forming systems, which cover only a minor part of chiral substances. In this paper, a hybrid process is proposed that extends the applicability of the preferential crystallization principle to the more common racemic compound forming systems. It comprises a preliminary (e. g. chromatographic) enantiomeric enrichment step and preferential crystallization to finally produce the desired pure enantiomer(s). The applicability of preferential crystallization to racemic compounds is demonstrated on the example of mandelic acid as a model system. Direct monitoring of the separation progress is performed using combined online polarimetry and online density measurements. A cyclic crystallization process, which provides alternating the pure mandelic acid enantiomer and the racemic compound, is feasible and allows the resolution of rac-mandelic acid as part of the proposed hybrid approach. Copyright © 2006 Wiley-Liss, Inc. [accessed 2013 November 27th]

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Language(s): eng - English
 Dates: 2006
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 287901
DOI: 10.1002/chir.20327
Other: 22/06
 Degree: -

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Title: Chirality
  Other : Chirality
Source Genre: Journal
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Publ. Info: New York : J. Wiley
Pages: - Volume / Issue: 18 (10) Sequence Number: - Start / End Page: 828 - 840 Identifier: ISSN: 0899-0042
CoNE: https://pure.mpg.de/cone/journals/resource/954925561581