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  Chromatographic enantioseparation of amino acids using a new chiral stationary phase based on a macrocyclic glycopeptide antibiotic

Petrusevska, K., Kuznetsov, M. A., Gedicke, K., Meshko, V., Staroverov, S. M., & Seidel-Morgenstern, A. (2006). Chromatographic enantioseparation of amino acids using a new chiral stationary phase based on a macrocyclic glycopeptide antibiotic. Journal of Separation Science, 29(10), 1447-1457. doi:10.1002/jssc.200600036.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9B30-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-8048-0
Genre: Journal Article

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 Creators:
Petrusevska, K.1, Author              
Kuznetsov, M. A.2, Author
Gedicke, K.3, Author              
Meshko, V.1, Author
Staroverov, S. M.2, Author
Seidel-Morgenstern, A.3, 4, Author              
Affiliations:
1Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University, Republic of Macedonia, ou_persistent22              
2Chemistry Department, Lomonosov State University, Russian Federation, ou_persistent22              
3Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
4Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Amino acids; Chromatographic enantioseparation; Eremomycin; Macrocyclic glycopeptide antibiotics
 Abstract: The separation of the enantiomers of several α-amino acids was studied on a new chiral stationary phase (CSP) which is based on the macrocyclic glycopeptide antibiotic eremomycin attached to silica particles. Retention and separation factors were determined under analytical conditions at ambient temperature for different mobile phase compositions. In order to evaluate the potential with respect to preparative separations the adsorption isotherms of D- and L-methionine were determined for one mobile phase composition applying the elution by characteristic point method. The isotherms were validated by comparing experimentally determined elution profiles with predictions based on the equilibrium dispersive model. Finally, the performance of the eremomycin CSP was compared with a commercially available CSP based on the macrocyclic antibiotic teicoplanin. After determining the isotherms of D- and L-methionine also for the teicoplanin phase, the equilibrium dispersive model was used for both CSP to identify optimal operating conditions. For the separation and conditions considered the new eremomycin CSP revealed a better performance compared to the teicoplanin CSP. Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [accessed February 8th 2013]

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Language(s): eng - English
 Dates: 2006
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 298309
DOI: 10.1002/jssc.200600036
Other: 34/06
 Degree: -

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Title: Journal of Separation Science
Source Genre: Journal
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Publ. Info: Weinheim, Fed. Rep. of Germany : Wiley-VCH
Pages: - Volume / Issue: 29 (10) Sequence Number: - Start / End Page: 1447 - 1457 Identifier: ISSN: 1615-9306
CoNE: https://pure.mpg.de/cone/journals/resource/954925570853