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  Using Chemical Reaction Network Theory to discard a Kinetic Mechanism Hypothesis

Conradi, C., Saez-Rodriguez, J., Gilles, E. D., & Raisch, J. (2005). Using Chemical Reaction Network Theory to discard a Kinetic Mechanism Hypothesis. IEE Proceedings Systems Biology, 152(4), 243-248. doi:10.1049/ip-syb:20050045.

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 Creators:
Conradi, Carsten1, Author
Saez-Rodriguez, Julio2, Author              
Gilles, Ernst Dieter2, Author              
Raisch, Jörg1, 3, Author              
Affiliations:
1Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
2Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              
3Systems and Control Theory, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738154              

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Free keywords: Chemical Reaction Network Theory; Model discrimination; MAPK-cascade
 Abstract: Feinberg’s Chemical Reaction Network Theory (CRNT) connects the structure of a biochemical reaction network to qualitative properties of the corresponding system of ordinary differential equations. In particular, no information about parameter values is needed. As such, it seems to be well suited for application in systems biology, where parameter uncertainty is predominant. However, its application in this area is rare, at best. To demonstrate potential benefits from the application, different reaction networks representing a single layer of the well studied Mitogen-activated protein kinase (MAPK) cascade are analyzed. Recent results from Markevich et al. (2004) show that, unexpectedly, multilayered protein kinase cascades can exhibit multistationarity even on a single cascade level. Using CRNT, we show that their assumption of a distributive mechanism for double phosphorylation and dephosphorylation is crucial for multistationarity on the single cascade level. © Copyright 2013 IEEE - All rights reserved [accessed 2013 June 13th]

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: Peer
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Title: IEE Proceedings Systems Biology
Source Genre: Journal
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Pages: - Volume / Issue: 152 (4) Sequence Number: - Start / End Page: 243 - 248 Identifier: -