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  Domain-oriented and modular approaches to the reduction of mathematical models of signaling networks

Saez-Rodriguez, J., Conzelmann, H., Sauter, T., Kholodenko, B. N., & Gilles, E. D. (2005). Domain-oriented and modular approaches to the reduction of mathematical models of signaling networks. Talk presented at 4th Workshop on Computation of Biochemical Pathways and Genetic Networks and Genetic Networks. Heidelberg, Germany. 2005-09-12 - 2005-09-13.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9BB7-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-C0FE-A
Genre: Talk

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 Creators:
Saez-Rodriguez, J.1, Author              
Conzelmann, H.1, 2, Author              
Sauter, T.1, 3, Author              
Kholodenko, B. N., Author
Gilles, E. D.1, Author              
Affiliations:
1Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              
2Inst. for System Dynamics and Control Engineering, Univ. of Stuttgart, persistent:22              
3Univ. of Stuttgart, Inst. for System Dynamics and Control Engineering, Stuttgart, Germany, persistent:22              

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 Abstract: A rigorous, detailed description of signaling networks gives rise to huge models, while an a priori simplified model relies on assumptions difficult to prove. Therefore, models which are manageable, yet retain the essential properties of the real network, are desirable. Herein, we first describe a method that addresses the combinatorial explosion of the number of states due to the ability of proteins to bind multiple partners via different domains. We show how a linear state transformation together with the application of the system-theoretical concept of observability allow a dramatic reduction of the number of states to be considered. Secondly, we present an approach for a further reduction of the models, based on a decomposition of the model into modules. The resulting subunits are analyzed via simulation studies, leading to the identification of less complex non-linear models showing approximately the same input/output behavior, which can replace the complex modules in the whole model.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Not specified
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239991
 Degree: -

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Title: 4th Workshop on Computation of Biochemical Pathways and Genetic Networks and Genetic Networks
Place of Event: Heidelberg, Germany
Start-/End Date: 2005-09-12 - 2005-09-13

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