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  Estimation of breakthrough behavior in fixed-bed and expanded-bed adsorption

Balleda, A., Pushpavanam, S., Nayak, D., Gueorguieva, L., & Seidel-Morgenstern, A. (2005). Estimation of breakthrough behavior in fixed-bed and expanded-bed adsorption. Poster presented at PREP '05:18th International Symposium on Preparative and Industrial Chromatography, Philadelphia, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9C32-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0025-0A91-0
Genre: Poster

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 Creators:
Balleda, A.1, Author
Pushpavanam, S.1, Author              
Nayak, D., Author
Gueorguieva, L.2, 3, Author              
Seidel-Morgenstern, A.2, 3, Author              
Affiliations:
1Dep. of Chemical Engineering, Indian Institute of Tech., Madras, Chennai, India, persistent:22              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Abstract: Understanding and predicting the performance of a chromatographic separation process primarily requires reliable information on the distribution of the components of a mixture between the mobile and stationary phases under equilibrium conditions. In this work we discuss results of studying the adsorption of Lysozyme on modified Sepharose matrices (STREAMLINE SP, Amersham Biosciences). Experiments were carried out with (a) packed beds and (b) in the expanded bed mode. Frontal analysis has been used to determine the adsorption isotherms from different experimental runs with the packed bed. The isotherms were fitted using both a Langmuir as well as a rectangular isotherm. The isotherms were verified by predicting further fixed bed breakthrough curves and comparing the results with experiments. Subsequently, the porosity and the dispersion coefficient of an expanded bed were estimated analyzing selected experimental results for one feed concentrations. Finally, all parameters determined were used to predict the performance of the expanded bed for different feed concentrations.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Not specified
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 221023
 Degree: -

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Title: PREP '05 :18th International Symposium on Preparative and Industrial Chromatography
Place of Event: Philadelphia, USA
Start-/End Date: 2005-05-08 - 2005-05-11

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