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  Analysis of applying different solvents for the mobile phase and for sample injection

Gedicke, K., Tomusiak, M., Antos, D., & Seidel-Morgenstern, A. (2005). Analysis of applying different solvents for the mobile phase and for sample injection. Journal of Chromatography A, 1092(1), 142-148. doi:10.1016/j.chroma.2005.02.059.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9CE5-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B831-5
Genre: Journal Article

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 Creators:
Gedicke, K.1, Author              
Tomusiak, M.2, Author
Antos, D.1, 2, Author              
Seidel-Morgenstern, A.1, 3, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Rzeszow Univ Technol, Rzeszow, Poland, persistent:22              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: Preparative chromatography; Caolumn overloading; Band splitting; Solubility limits; Crystallisation
 Abstract: Overloading a chromatographic column with a compound possessing low solubility in the mobile phase has been investigated. In order to increase the concentration of injection a strong solvent for dissolving the feed was used. The injection of such concentrated samples brings the risk of triggering undesired crystallisation processes. A model system has been investigated with ethanol water as the mobile phase and dl-threonine as the sample dissolved in pure water. Under extreme overloaded conditions band splitting was observed. Measurements of the adsorption isotherms and systematic solubility studies were carried out. For the process analysis a simplified mathematical model was applied. The simulations of the band profiles were compared with the experimental data. © 2005 Elsevier B.V. All rights reserved. [accessed 2013 November 27th]

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 238050
Other: 37/05
DOI: 10.1016/j.chroma.2005.02.059
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1092 (1) Sequence Number: - Start / End Page: 142 - 148 Identifier: ISSN: 0021-9673
CoNE: https://pure.mpg.de/cone/journals/resource/954925527837_1