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  Shortcut Method for Evaluation and Design of a Hybrid Process for Enantioseparations

Kaspereit, M., Gedicke, K., Zahn, V., Mahoney, A. W., & Seidel-Morgenstern, A. (2005). Shortcut Method for Evaluation and Design of a Hybrid Process for Enantioseparations. Journal of Chromatography A, 1092(1), 43-54. doi:10.1016/j.chroma.2005.02.043.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9CE9-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B846-8
Genre: Journal Article

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 Creators:
Kaspereit, M.1, Author              
Gedicke, K.1, Author              
Zahn, V.1, Author              
Mahoney, A. W.1, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Abstract: Hybrid processes for enantioseparations have a considerable potential for reducing investment and operational costs. An example is the combination of simulated moving bed (SMB) chromatography and selective crystallisation. However, the design of integrated processes is a difficult task. A shortcut method is presented that can serve as a tool for design and estimation of the potential of such processes. The approach requires only limited experimental data and thus allows for systematic parameters studies. The method is based on the determination of the purity-performance characteristic of the SMB process and rigorous application of mass balances. The use of relative mass fluxes allows derivation of simple algebraic expressions for essential process parameters. The significant potential of combining SMB and crystallisation is demonstrated for the example of the separation of mandelic acid enantiomers. © 2005 Elsevier B.V. All rights reserved. [accessed 2013 November 27th]

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 238098
Other: 14/05
DOI: 10.1016/j.chroma.2005.02.043
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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 1092 (1) Sequence Number: - Start / End Page: 43 - 54 Identifier: ISSN: 0021-9673
CoNE: https://pure.mpg.de/cone/journals/resource/954925527837_1