English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Detailed study of Tröger's base separation by SMB process

Mihlbachler, K., Seidel-Morgenstern, A., & Guiochon, G. (2004). Detailed study of Tröger's base separation by SMB process. AIChE-Journal, 50, 611-624. doi:10.1002/aic.10055.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9E71-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B89C-6
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Mihlbachler, K.1, 2, 3, 4, Author
Seidel-Morgenstern, A.1, 5, Author              
Guiochon, G.2, 3, Author
Affiliations:
1Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
2University of Tennessee, Dept. of Chemistry, Knoxville, TN United States , ou_persistent22              
3Division of Chemical Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, United States, ou_persistent22              
4Eli Lilly and Company, Indianapolis, IN, United States , ou_persistent22              
5Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              

Content

show
hide
Free keywords: -
 Abstract: This investigation of the separation of Tröger's base by the SMB process demonstrates: (1) the major importance of a proper modeling of the separation in order to determine the optimal operating conditions; (2) the need of an accurate modeling of the adsorption isotherms of the feed components. The adsorption of Tröger's base onto the stationary phase ChiralPak AD was successfully described by multilayer adsorption isotherm models. Due to the complexity of these models, the region of suitable operating parameters cannot be determined algebraically by the equilibrium theory. As an alternative, the equilibrium-dispersive model, and a reliable numerical algorithm were used to scan a wide operating region, and to define this separation area. To verify the results of these calculations, the separation area was also experimentally detected by performing measurements of product purity and production rate for selected operating points. The combination of a UV detector and a polarimeter allows the accurate monitoring of the internal concentration profiles of both enantiomers. These profiles were compared to the profiles calculated using the multilayer adsorption isotherm models. In addition, the influence of the heterogeneity of the column set on the performance of the SMB process, is studied. Even under strongly nonlinear conditions, excellent agreements between calculated and experimental profiles were obtained. Copyright © 2004 American Institute of Chemical Engineers (AIChE) [accessed 2013 November 27th]

Details

show
hide
Language(s): eng - English
 Dates: 2004
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 207914
Other: 53/04
DOI: 10.1002/aic.10055
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: AIChE-Journal
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : American Institute of Chemical Engineers (AIChE)
Pages: - Volume / Issue: 50 Sequence Number: - Start / End Page: 611 - 624 Identifier: ISSN: 0001-1541
CoNE: https://pure.mpg.de/cone/journals/resource/954925372782