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  Linear two-step gradient counter-current chromatography : analysis based on a recursive solution of an equilibrium stage model

Beltscheva, D., Hugo, P., & Seidel-Morgenstern, A. (2003). Linear two-step gradient counter-current chromatography: analysis based on a recursive solution of an equilibrium stage model. Journal of Chromatography A, 989(1), 31-45. doi:10.1016/S0021-9673(02)01962-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-9F6D-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-B9F6-3
Genre: Journal Article
Alternative Title : J. Chromatogr. A

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 Creators:
Beltscheva, D.1, Author
Hugo, P.1, Author
Seidel-Morgenstern, A.2, 3, Author              
Affiliations:
1Tech Univ Berlin, Inst Tech Chem, Berlin, Germany, ou_persistent22              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: counter-current chromatography; gradient elution; adsorption isotherms; equilibrium stage model; mathematical modeling; preparative chromatography
 Abstract: The implementation of gradients in continuously operated chromatographic counter-current processes has recently attracted considerable interest as a method to improve the performance of this effective separation method. If liquid mobile phases are applied it is advantageous to set the solvent strength in the desorbent stream higher than that in the feed stream. As a consequence, the components to be separated are more retained in the adsorption zones and more easily eluted in the desorption zones. Due to the additional degrees of freedom the design and the optimization of such a two-step gradient counter-current process is difficult. In this paper a steady state equilibrium stage model is used to simulate the process under linear conditions. A simple solution of the underlying model equations is presented capable to describe efficiently the unit for large stage numbers typically encountered in chromatographic columns. Due to the rapidity of the algorithm developed a broad range of operating conditions can be evaluated systematically for different types of gradients. The impact of (a) the functional dependence of the adsorption equilibrium constants on the solvent composition, (b) the number of equilibrium stages and (c) the specification of purity requirements is illustrated and discussed based on results of parametric calculations. The results achieved emphasize the potential of two-step gradient counter-current chromatography. copyright 2003 Elsevier B.V. All rights reserved. [accessed 2013 November 28th]

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Language(s): eng - English
 Dates: 2003
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 13816
DOI: 10.1016/S0021-9673(02)01962-3
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 989 (1) Sequence Number: - Start / End Page: 31 - 45 Identifier: ISSN: 0021-9673
CoNE: https://pure.mpg.de/cone/journals/resource/954925527837_1