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  Solubility equilibria in chiral systems and their importance for enantioseparation

Lorenz, H., Sapoundjiev, D., & Seidel-Morgenstern, A. (2003). Solubility equilibria in chiral systems and their importance for enantioseparation. Engineering in Life Sciences, 3(3), 132-136. doi:10.1002/elsc.200390016.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A005-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-ACF4-D
Genre: Journal Article

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 Creators:
Lorenz, H.1, Author              
Sapoundjiev, D.1, 2, Author              
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Abstract: Ternary solubility equilibria are studied for three chiral systems in various aqueous and nonaqueous solvents. The chosen systems were a pharmaceutical intermediate, threonine and mandelic acid. Measured solubility data are presented and the nature of the ternary solubility phase diagrams is described. On this basis possible procedures for a crystallization based enantioseparation are derived. Also, the impact of solubility equilibria on the resolution of racemates by liquid chromatography is analyzed and discussed for the systems under investigation. Finally, a hybrid approach coupling both separation techniques for an efficient chiral resolution is demonstrated by means of the fundamental solubility phase diagrams. © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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Language(s): eng - English
 Dates: 2003
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 125071
Other: 22/03
DOI: 10.1002/elsc.200390016
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Title: Engineering in Life Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 3 (3) Sequence Number: - Start / End Page: 132 - 136 Identifier: ISSN: 1618-0240