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  Use of network analysis of metabolic systems in bioengineering

Schuster, S., Klamt, S., Weckwerth, W., Moldenhauer, F., & Pfeiffer, T. (2002). Use of network analysis of metabolic systems in bioengineering. Bioprocess and Biosystems Engineering, 24(6), 363-372. doi:10.1007/s004490100253.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A0A7-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B87B-D
Genre: Journal Article
Alternative Title : Bioprocess. Biosyst. Eng.

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 Creators:
Schuster, S.1, Author
Klamt, S.2, Author              
Weckwerth, W.3, Author              
Moldenhauer, F.1, Author
Pfeiffer, T.4, Author
Affiliations:
1Max Delbruck Ctr Mol Med, Dept Bioinformat, D-13092 Berlin, Germany; Max Planck Inst Mol Plant Physiol, D-14476 Golm, Germany; ETH Ctr Zurich, CH-8092 Zurich, Switzerland, ou_persistent22              
2Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              
3Integrative Proteomics and Metabolomics, Department Stitt, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753334              
4ETH Centre, Zürich, Switzerland , ou_persistent22              

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 Abstract: Basic ideas and recent developments in network analysis of metabolic systems and various applications of this analysis in bioengineering are reviewed. Central concepts are the null- space to the stoichiometry matrix and the elementary flux modes. The applicability of elementary-modes analysis in biotechnology is illustrated by the synthesis of the cyclooctadepsipeptides PF1022 in the fungus Mycelia sterilia. Network analysis is also useful in metabolic flux analysis. In particular, a procedure for finding out which reaction rates can be uniquely calculated in underdetermined reaction networks is outlined. The concept of 'enzyme subsets' is explained and its use for analysing genetic regulation is demonstrated. In particular, the correlation between expression data concerning the diauxic shift in yeast and the enzyme subsets in yeast metabolism is discussed. © Copyright 2008 Elsevier B.V., All rights reserved. [Accessed 2013 June 13th]

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s004490100253
eDoc: 13759
 Degree: -

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Title: Bioprocess and Biosystems Engineering
  Alternative Title : Bioprocess. Biosyst. Eng.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 24 (6) Sequence Number: - Start / End Page: 363 - 372 Identifier: ISSN: 1615-7591