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  Two-step solvent gradients in simulated moving bed chromatography - Numerical study for linear equilibria

Antos, D., & Seidel-Morgenstern, A. (2002). Two-step solvent gradients in simulated moving bed chromatography - Numerical study for linear equilibria. Journal of Chromatography A, 944(1-2), 77-91. doi:10.1016/S0021-9673(01)01365-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A0AB-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B6E0-8
Genre: Journal Article
Alternative Title : J. Chromatogr. A

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 Creators:
Antos, D.1, 2, Author              
Seidel-Morgenstern, A.2, 3, Author              
Affiliations:
1Rzeszow Univ Technol, Rzeszow, Poland, persistent:22              
2Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: gradient elution; simulated moving bed chromatography; true moving beds; adsorption isotherms; mathematical modelling
 Abstract: The application of gradients in simulated moving bed (SMB) chromatography has recently attracted interest as a method for further improving the performance of this continuous separation process. One possible implementation of gradients consists in setting the solvent strength in the desorbent stream higher than that in the feed stream. As a result, the components to be separated are more retained in the zones upstream of the feed position and more easily eluted in the zones downstream of the feed position. If a liquid mobile phase is used, gradients can be created by, dosing different solvents into the feed and desorbent ports. In a closed-loop gradient SMB arrangement the solvent strength within the unit will depend on the two feed compositions and on the characteristic flow-rates of the process. In this work an equilibrium stage model describing a true moving bed process is used to analyze, numerically the main features of a two-step gradient SMB process. The adsorption isotherms are assumed to be always linear under isocratic conditions. The relevant Henry constants depend in a nonlinear manner on the composition of the solvent. Based on numerical simulations the impact of the two inlet solvent compositions is demonstrated in terms of the size and shape of regions of applicable flow-rates. Different strategies of designing the process are discussed and compared with respect to maximizing productivities and minimizing desorbent requirements. (C) 2002 Elsevier Science BV All rights reserved. [accessed 2013 November 29th]

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 13743
DOI: 10.1016/S0021-9673(01)01365-6
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 944 (1-2) Sequence Number: - Start / End Page: 77 - 91 Identifier: ISSN: 0021-9673
CoNE: /journals/resource/954925527837_1