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  Impact of adsorption isotherm parameters on the performances of enantioseparation using simulated moving bed chromatography

Kaspereit, M., Jandera, P., Skavrada, M., & Seidel-Morgenstern, A. (2002). Impact of adsorption isotherm parameters on the performances of enantioseparation using simulated moving bed chromatography. Journal of Chromatography A, 944(1-2), 249-262. doi:10.1016/S0021-9673(01)01341-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A0AD-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-BA31-6
Genre: Journal Article
Alternative Title : J. Chromatogr. A

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 Creators:
Kaspereit, M.1, Author              
Jandera, P.2, Author
Skavrada, M.2, Author
Seidel-Morgenstern, A.1, 3, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Univ Pardubice, Dept Analyt Chem, Pardubice, Czech Republic, ou_persistent22              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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Free keywords: adsorption isotherms; enantiomer separation; simulated moving bed chromatography; preparative chromatography; mandelic acid
 Abstract: Often there are several chromatographic systems, i.e., combinations of mobile and stationary phases, available to solve a certain separation problem. Essential differences of these chromatographic systems are the separation factors and the efficiencies. For preparative applications in addition also the column saturation capacities and solubility limits are of importance. The impact of all these parameters appears to be rather well understood for conventional overloaded elution chromatography using a single column. In the last years the continuous simulated moving bed (SMB) process was increasingly used as a powerful alternative to batch elution since increased productivities and reduced solvent consumptions could be realised. However, the selection of suitable chromatographic systems is more, sophisticated for this process. In this paper five different chromatographic systems capable of separating the enantiomers of mandelic acid are compared based on the achievable productivities using SMB chromatography. For these five systems the adsorption isotherms have been determined experimentally. Subsequently, an analysis of the SMB process was performed numerically using a well-established model. (C) 2002 Elsevier Science B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 13747
DOI: 10.1016/S0021-9673(01)01341-3
 Degree: -

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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 944 (1-2) Sequence Number: - Start / End Page: 249 - 262 Identifier: ISSN: 0021-9673
CoNE: /journals/resource/954925527837_1