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  Calculating as many fluxes as possible in underdetermined metabolic networks

Klamt, S., & Schuster, S. (2002). Calculating as many fluxes as possible in underdetermined metabolic networks. Molecular Biology Reports, 29(1-2), 243-248. doi:10.1023/A:1020394300385.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A0C1-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F490-D
Genre: Journal Article
Alternative Title : Mol. Biol. Rep.

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 Creators:
Klamt, S.1, Author              
Schuster, S.2, Author
Affiliations:
1Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              
2Max Delbruck Ctr Mol Med, Dept Bioinformat, D-13092 Berlin, Germany, ou_persistent22              

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 Abstract: A frequently occurring problem in Metabolic Flux Analysis is that the linear equation systems are underdetermined. A procedure for determining which reaction velocities can be calculated in underdetermined metabolic systems from measured rates and computing these velocities is given. The method is based on the null-space matrix to the stoichiometry matrix corresponding to the reactions with unknown velocities. Moreover, an elementary representation of the null-space is presented. This representation enables one to find those sets of measurable velocities that allow calculation of a certain non-measurable rate. The approach is illustrated by an example from monosaccharide metabolism. © Copyright 2008 Elsevier B.V., All rights reserved. [accessed 2013 June 13th]

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1023/A:1020394300385
eDoc: 13790
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Title: Molecular Biology Reports
  Alternative Title : Mol. Biol. Rep.
Source Genre: Journal
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Pages: - Volume / Issue: 29 (1-2) Sequence Number: - Start / End Page: 243 - 248 Identifier: ISSN: 0301-4851