English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Steady state multiplicity in bioreactors: bifurcation analysis of cybernetic models

Namjoshi, A., Kienle, A., & Ramkrishna, D. (2002). Steady state multiplicity in bioreactors: bifurcation analysis of cybernetic models. In 17th Symposium on Chemical Reaction Engineering ISCRE 17 (pp. 1-6).

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A106-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0024-B6B5-A
Genre: Conference Paper

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Namjoshi, A., Author
Kienle, A.1, 2, Author              
Ramkrishna, D., Author
Affiliations:
1Process Synthesis and Process Dynamics, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738153              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

Content

show
hide
Free keywords: -
 Abstract: Biological systems have an additional level of complexity compared to other chemical systems because of the effects of metabolic regulation. Such regulation in the form of control of enzyme synthesis and activity leads to nonlinear behavior in bioreactors. Mathematical models that take into account these control mechanisms can be very successful in capturing the peculiarities of bioreactors such as multiple steady states and periodic phenomena. Cybernetic models, which are extremely suitable for this task model expression and activation of enzymes by the use of cybernetic control variables and have been used to explain multiplicities in hybridoma reactors. In particular, the cybernetic model of Namjoshi et al. (2002) has been able to predict the transition from batch and fed-batch to continuous culture in hybridoma experiments of Europa et al. The multiple steady states that result, vary widely in the concentration of cell mass and waste metabolites. The model captures the multiplicity of steady states for the hybridoma reactors. The bifurcation analysis of such models reveals the steady state behavior under a range of operating conditions and can be used to plan bioreactor operation to get the desired staedy states for maximum productivity.

Details

show
hide
Language(s):
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 35013
 Degree: -

Event

show
hide
Title: 17th Symposium on Chemical Reaction Engineering, ISCRE 17
Place of Event: Hong Kong, China
Start-/End Date: 2002-08-25 - 2002-08-28

Legal Case

show

Project information

show

Source 1

show
hide
Title: 17th Symposium on Chemical Reaction Engineering ISCRE 17
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: CD-ROM Volume / Issue: - Sequence Number: subsession E-3 Start / End Page: 1 - 6 Identifier: -