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  Measurement and modeling of the equilibrium behavior of the Tröger's base enantiomers on an amylose-based chiral stationary phase

Mihlbachler, K., Kaczmarski, K., Seidel-Morgenstern, A., & Guiochon, G. (2002). Measurement and modeling of the equilibrium behavior of the Tröger's base enantiomers on an amylose-based chiral stationary phase. Journal of Chromatography A, 955(1), 35-52. doi:10.1016/S0021-9673(02)00228-5.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A10E-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-BA4D-A
Genre: Journal Article

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Mihlbachler, K.1, 2, 3, Author
Kaczmarski, K.2, 4, Author
Seidel-Morgenstern, A.1, 5, Author              
Guiochon, G.2, 3, Author
Affiliations:
1Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
2Department of Chemistry, University of Tennessee, Knoxville, TN 37996-1600, United States , ou_persistent22              
3Division of Chemical and Analytical Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6120, United States , ou_persistent22              
4 Rzeszòw University of Technology, Rzeszòw, Poland , ou_persistent22              
5Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              

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 Abstract: The binary isotherms of the two enantiomers of Tröger’s base were measured on a system made of pure 2-propanol as the mobile phase and of Chiralpak AD, a chiral stationary phase (CSP) based on amylose tri-(3,5-dimethylphenyl carbamate). The experimental data were acquired using both frontal analysis and the perturbation method. The results obtained are most unusual. The adsorption of the more-retained (-)-enantiomer is not competitive: the amount adsorbed onto the CSP at equilibrium with a constant concentration of the (-)-enantiomer is independent of the concentration of the (+)-enantiomer. On the other hand, the adsorption of the less-retained enantiomer is cooperative: the amount of this (+)-enantiomer adsorbed by the CSP at equilibrium with a constant concentration of this enantiomer increases with increasing concentration of the (-)-enantiomer. Such a phenomenon has hardly ever been reported. A model equation is proposed that account well for all these isotherm data. 2002 Elsevier Science B.V. All rights reserved. [accessed 2013 November 29th]

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 Dates: 2002
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: eDoc: 35025
DOI: 10.1016/S0021-9673(02)00228-5
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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 955 (1) Sequence Number: - Start / End Page: 35 - 52 Identifier: ISSN: 0021-9673
CoNE: /journals/resource/954925527837_1