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  Effect of the homogeneity of the column set on the performance of a simulated moving bed unit. Part II: Experimental study

Mihlbachler, K., Jupke, A., Seidel-Morgenstern, A., Schmidt-Traub, H., & Guiochon, G. (2002). Effect of the homogeneity of the column set on the performance of a simulated moving bed unit. Part II: Experimental study. Journal of Chromatography A, 944(1-2), 3-22. doi:10.1016/S0021-9673(01)01396-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A116-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-BA46-7
Genre: Journal Article

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Mihlbachler, K.1, 2, 3, Author
Jupke, A.4, Author
Seidel-Morgenstern, A.1, 5, Author              
Schmidt-Traub, H.4, Author
Guiochon, G.2, 3, Author
Affiliations:
1Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
2Department of Chemistry, University of Tennessee, Knoxville, TN, United States , ou_persistent22              
3Division of Chemical and Analytical Sciences, Oak Ridge National Laboratory, Oak Ridge, TN, United States , ou_persistent22              
4University of Dortmund, Department of Chemical Engineering, Dortmund, Germany, ou_persistent22              
5Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              

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 Abstract: Previous studies of the simulated moving bed (SMB) process assume identical characteristics of all the columns incorporated in a given unit. Due to the practical impossibility to manufacture identical columns, numerical applications of the theory to modeling and optimization use for each of the needed column parameter the average value for the entire column set. In this study, the effects of these simplifications on the actual productivity of the SMB process are evaluated by making exact calculations, i.e., by taking the differences in the porosity values into account. We apply a revised set of separation conditions previously introduced and derived from the eqiuilibrium theory. Earlier theoretical results are compared to experimental results obtained in the study of the enantiomeric separation of Troger‘s base on Chiralpak AD. Due to the non Langmuirian character of the adsorption isotherms of these two compounds on the packing material used, the separation area cannot be determined analytically. As an alternative, a reliable numerical algorithm was used to scan a wider region and to define the separation area. The form of this area depends on the applied porosity values. A UV detector and a laser polarimeter located at one node of the SMB monitor on-line the internal concentration profiles. Excellent agreement between the calculated and the experimentally determined concentration profiles was obtained under nonlinear conditions. The influence of column-to-column variations on the performance of the SMB process was found to be more significant under nonlinear than under linear conditions. 2002 Elsevier Science B.V. All rights reserved. [accessed 2013 November 29th]

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 Dates: 2002
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: eDoc: 35076
DOI: 10.1016/S0021-9673(01)01396-6
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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 944 (1-2) Sequence Number: - Start / End Page: 3 - 22 Identifier: ISSN: 0021-9673
CoNE: /journals/resource/954925527837_1