English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactose

Kremling, A., Bettenbrock, K., Laube, B., Jahreis, K., Lengeler, J. W., & Gilles, E. D. (2001). The organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactose. Metabolic Engineering, 3(4), 362-379. doi:10.1006/mben.2001.0199.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A13C-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-ACF9-F
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kremling, A.1, Author              
Bettenbrock, K.1, Author              
Laube, Britta1, Author              
Jahreis, K.2, Author
Lengeler, J. W.2, Author
Gilles, E. D.1, Author              
Affiliations:
1Systems Biology, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738155              
2Univ Osnabrück, Fachbereich Biol Chem, D-4500 Osnabrück, Germany, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: A mathematical model to describe carbon catabolite repression in Escherichia coli is developed and in part validated. The model is aggregated from two functional units describing glucose and lactose transport and degradation. Both units are members of the erp modulon and are under control of a global signal transduction system which calculates the signals that turn on or off gene expression for the specific enzymes. Using isogenic mutant strains, our model is validated by a set of experiments. In these experiments, substrate composition of the preculture and of the experimental culture are varied in order to stimulate the system in different ways. With the obtained measurements (three states in the liquid phase and one intracellular component) a part of the model parameters could be estimated. Therefore all experiments could be sufficiently described with a single set of parameters. (C) 2001 Academic Press.

Details

show
hide
Language(s): eng - English
 Dates: 2001
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 13753
DOI: 10.1006/mben.2001.0199
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Metabolic Engineering
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 3 (4) Sequence Number: - Start / End Page: 362 - 379 Identifier: ISSN: 1096-7176