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  Coupling of simulated moving bed chromatography and fractional crystallisation for efficient enantioseparation

Lorenz, H., Sheehan, P., & Seidel-Morgenstern, A. (2001). Coupling of simulated moving bed chromatography and fractional crystallisation for efficient enantioseparation. Journal of Chromatography A, 908(1-2), 201-214. doi:10.1016/S0021-9673(00)00992-4.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A1BB-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-BA5D-4
Genre: Journal Article

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Lorenz, H.1, Author              
Sheehan, P.2, Author
Seidel-Morgenstern, A.1, 2, Author              
Affiliations:
1Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              
2Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              

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 Abstract: An optimised coupling of liquid chromatography and fractional crystallisation is suggested for efficient enantioseparation. As a first stage, a chromatographic separation, preferably simulated moving bed chromatography (SMB), is applied to achieve an enantiomeric enrichment sufficient for a subsequent crystallisation. First results of the experimental and modelling work for the model system (+)-/(-)-mandelic acid in an aqueous solution are described. Chromatographic investigations involve the estimation of adsorption isotherms on a suitable chiral stationary phase and the simulation and optimisation of a corresponding SMB-process. From the ternary phase diagram measured for the (+)-/(-)-enantiomer/solvent system, the conditions required to crystallise a pure enantiomer from an asymmetric mixture can be derived. The productivity gains achievable from the combined process compared to the application of chromatography alone are discussed. © 2001 Elsevier Science B.V. [accessed 2013 November 29th]

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 Dates: 2001
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 63065
DOI: 10.1016/S0021-9673(00)00992-4
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Title: Journal of Chromatography A
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 908 (1-2) Sequence Number: - Start / End Page: 201 - 214 Identifier: ISSN: 0021-9673
CoNE: https://pure.mpg.de/cone/journals/resource/954925527837_1