English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Separation of enantiomers using simulated moving bed-chromatography

Kniep, H., Mann, G., Vogel, C., & Seidel-Morgenstern, A. (2000). Separation of enantiomers using simulated moving bed-chromatography. Chemical Engineering and Technology, 23(10), 853-857. doi:10.1002/1521-4125(200010)23:10<853:AID-CEAT853>3.0.CO;2-2.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A23A-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0014-BA6A-6
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Kniep, H.1, Author
Mann, G.2, Author
Vogel, C.3, Author
Seidel-Morgenstern, A.3, 4, Author              
Affiliations:
1Axiva GmbH, D-65926 Frankfurt, Germany , ou_persistent22              
2 Schering AG, D-13342 Berlin, Germany , ou_persistent22              
3Otto-von-Guericke-Universität Magdeburg, External Organizations, ou_1738156              
4Physical and Chemical Foundations of Process Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Max Planck Society, ou_1738150              

Content

show
hide
Free keywords: -
 Abstract: Chemical synthesis as well as fermentation processes often lead to complex mixtures of products. For the separation of the often thermally labile products, the application of a gentle and selective method like liquid chromatography is a suitable way to go. A broad range of procedures has recently been developed [1] and is used for the production of highly pure pharmaceutical and biotechnological substances. Special attention is paid at present to the resolution of racemic mixtures to yield optically pure enantiomers [2]. In addition to the ongoing optimization of discontinuous processes such as the classical elution (or batch) chromatography or recycling chromatography, at present much effort is put into the application of the Simulated Moving Bed (SMB) chromatography [3] - which is well established in petrochemistry and in sugar industry - for the usually difficult separation of enantiomers [e. g. 4 - 6]. In this paper the application of SMB-chromatography for the resolution of two racemic mixtures shall be described. First a simple mathematical model of the chromatographic process as well as the methods for the determination of the essential parameters are defined, then the results of various SMB experiments are presented and compared to model predictions. © 2000 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany [accessed 2013 November 29th]

Details

show
hide
Language(s):
 Dates: 2000
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Chemical Engineering and Technology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : J. Wiley
Pages: - Volume / Issue: 23 (10) Sequence Number: - Start / End Page: 853 - 857 Identifier: ISSN: 0930-7516
CoNE: https://pure.mpg.de/cone/journals/resource/991042744467904