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Abstract:
A modification of the perturbation method for measuring the isotherms of the adsorption of dissolved components on stationary phases is suggested. The general principle of the method is to analyze how the chromatographic system responses to small perturbations at different equilibrium concentrations. The perturbations can be introduced by injecting small samples of a solution with a concentration different than the equilibrium concentration. Essential advantages of this method are: (a) no detector calibration is required and (b) experiments with mixtures can be performed and analyzed efficiently if no pure components are available. Peculiarity of the method used in this work is the application of a closed-loop arrangement allowing the efficient exploitation of the sample. Experimental data for different chromatographic systems are presented to illustrate the method.
