English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Matrix-algebra-based calculations of the time evolution of the binary spin-bath model for magnetization transfer

Müller, D., Pampel, A., & Möller, H. E. (2013). Matrix-algebra-based calculations of the time evolution of the binary spin-bath model for magnetization transfer. Journal of Magnetic Resonance, 230, 88-97. doi:10.1016/j.jmr.2013.01.013.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A71D-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-8CAA-0
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Müller, Dirk1, Author              
Pampel, André1, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

Content

show
hide
Free keywords: Bloch–McConnell equations; Continuous-wave saturation; Matrix algebra; Polynomial interpolation; Pulsed saturation; Quantitative magnetization-transfer imaging
 Abstract: Quantification of magnetization-transfer (MT) experiments are typically based on the assumption of the binary spin-bath model. This model allows for the extraction of up to six parameters (relative pool sizes, relaxation times, and exchange rate constants) for the characterization of macromolecules, which are coupled via exchange processes to the water in tissues. Here, an approach is presented for estimating MT parameters acquired with arbitrary saturation schemes and imaging pulse sequences. It uses matrix algebra to solve the Bloch–McConnell equations without unwarranted simplifications, such as assuming steady-state conditions for pulsed saturation schemes or neglecting imaging pulses. The algorithm achieves sufficient efficiency for voxel-by-voxel MT parameter estimations by using a polynomial interpolation technique. Simulations, as well as experiments in agar gels with continuous-wave and pulsed MT preparation, were performed for validation and for assessing approximations in previous modeling approaches. In vivo experiments in the normal human brain yielded results that were consistent with published data.

Details

show
hide
Language(s): eng - English
 Dates: 2013-01-212012-05-232013-02-092013-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.jmr.2013.01.013
PMID: 23454578
Other: Epub 2013
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Magnetic Resonance
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Diego [etc.] : Academic Press
Pages: - Volume / Issue: 230 Sequence Number: - Start / End Page: 88 - 97 Identifier: ISSN: 0022-2364
CoNE: https://pure.mpg.de/cone/journals/resource/954922651175_1