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  Depression and incident dementia: An 8-year population-based prospective study

Luppa, M., Luck, T., Ritschel, F., Angermeyer, M. C., Villringer, A., & Riedel-Heller, S. G. (2013). Depression and incident dementia: An 8-year population-based prospective study. PLoS One, 8(3): e59246. doi:10.1371/journal.pone.0059246.

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Luppa, Melanie1, Author
Luck, Tobias1, 2, Author
Ritschel, Franziska1, Author
Angermeyer, Matthias C.3, 4, Author
Villringer, Arno5, 6, Author              
Riedel-Heller, Steffi G.1, 7, Author
Affiliations:
1Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
2Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
3Center for Public Mental Health, Goesing a. W., Austria, ou_persistent22              
4Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Italy, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

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 Abstract: AIMS: The aim of the study was to investigate the impact of depression (categorical diagnosis; major depression, MD) and depressive symptoms (dimensional diagnosis and symptom patterns) on incident dementia in the German general population. METHODS: Within the Leipzig Longitudinal Study of the Aged (LEILA 75+), a representative sample of 1,265 individuals aged 75 years and older were interviewed every 1.5 years over 8 years (mean observation time 4.3 years; mean number of visits 4.2). Cox proportional hazards and binary logistic regressions were used to estimate the effect of baseline depression and depressive symptoms on incident dementia. RESULTS: The incidence of dementia was 48 per 1,000 person-years (95% confidence interval (CI) 45-51). Depressive symptoms (Hazard ratio HR 1.03, 95% CI 1.01-1.05), and in particular mood-related symptoms (HR 1.08, 95% CI 1.03-1.14), showed a significant impact on the incidence of dementia only in univariate analysis, but not after adjustment for cognitive and functional impairment. MD showed only a significant impact on incidence of dementia in Cox proportional hazards regression, but not in binary logistic regression models. DISCUSSION: The present study using different diagnostic measures of depression on future dementia found no clear significant associations of depression and incident dementia. Further in-depth investigation would help to understand the nature of depression in the context of incident dementia. The aim of the study was to investigate the impact of depression (categorical diagnosis; major depression, MD) and depressive symptoms (dimensional diagnosis and symptom patterns) on incident dementia in the German general population. Methods Within the Leipzig Longitudinal Study of the Aged (LEILA 75+), a representative sample of 1,265 individuals aged 75 years and older were interviewed every 1.5 years over 8 years (mean observation time 4.3 years; mean number of visits 4.2). Cox proportional hazards and binary logistic regressions were used to estimate the effect of baseline depression and depressive symptoms on incident dementia. Results The incidence of dementia was 48 per 1,000 person-years (95% confidence interval (CI) 45–51). Depressive symptoms (Hazard ratio HR 1.03, 95% CI 1.01–1.05), and in particular mood-related symptoms (HR 1.08, 95% CI 1.03–1.14), showed a significant impact on the incidence of dementia only in univariate analysis, but not after adjustment for cognitive and functional impairment. MD showed only a significant impact on incidence of dementia in Cox proportional hazards regression, but not in binary logistic regression models. Discussion The present study using different diagnostic measures of depression on future dementia found no clear significant associations of depression and incident dementia. Further in-depth investigation would help to understand the nature of depression in the context of incident dementia.

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Language(s): eng - English
 Dates: 2012-08-202013-02-132013-03-19
 Publication Status: Published online
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1371/journal.pone.0059246
PMID: 23527147
PMC: PMC3602089
Other: Epub 2013
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (3) Sequence Number: e59246 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850