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  Organization of the human inferior parietal lobule based on receptor architectonics

Caspers, S., Schleicher, A., Bacha-Trams, M., Palomero-Gallagher, N., Amunts, K., & Zilles, K. (2013). Organization of the human inferior parietal lobule based on receptor architectonics. Cerebral Cortex, 23(3), 615-628. doi:10.1093/cercor/bhs048.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-A7D8-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-848A-C
Genre: Journal Article

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 Creators:
Caspers, Svenja1, Author
Schleicher, Axel2, Author
Bacha-Trams, Mareike1, 3, Author              
Palomero-Gallagher, Nicola1, Author
Amunts, Katrin1, 4, 5, Author
Zilles, Karl1, 2, 5, Author
Affiliations:
1Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
2C. and O. Vogt Institute for Brain Research, Heinrich Heine University Düsseldorf, Germany, ou_persistent22              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
4Jülich Aachen Research Alliance - JARA BRAIN, Jülich, Germany, ou_persistent22              
5Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen, Germany, ou_persistent22              

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Free keywords: Architecture; Cerebral cortex; Inferior parietal lobe; Structural segregation; Transmitter receptors
 Abstract: Human inferior parietal lobule (IPL) plays a key role in various cognitive functions. Its functional diversity, including attention, language, and action processing, is reflected by its structural segregation into 7 cytoarchitectonically distinct areas, each with characteristic connectivity patterns. We hypothesized that commonalities of the cytoarchitectonic, connectional, and functional diversity of the IPL should be reflected by a correlated transmitter receptor–based organization. Since the function of a cortical area requires a well-tuned receptor balance, the densities of 15 different receptors were measured in each IPL area. A hierarchical cluster analysis of the receptor balance revealed a tripartite segregation of the IPL into a rostral, middle, and caudal group. Comparison with other cortical areas showed strong similarities with Broca's region for all 3 groups, with the superior parietal cortex for the middle, and with extrastriate visual areas for the caudal group. Notably, caudal-most area PGp has a receptor fingerprint very similar to that of ventral extrastriate visual cortex. We therefore propose a new organizational model of the human IPL, consisting of 3 clusters, which corresponds to its known cytoarchitectonic, connectional, and functional diversity at the molecular level. This might reflect a general organizational principle of human IPL, beyond specific functional domains.

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Language(s): eng - English
 Dates: 2012-02-282013-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhs048
PMID: 22375016
PMC: PMC3563340
Other: Epub 2012
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 23 (3) Sequence Number: - Start / End Page: 615 - 628 Identifier: ISSN: 1047-3211
CoNE: /journals/resource/954925592440