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  Beyond cytoarchitectonics: The internal and external connectivity structure of the caudate nucleus

Kotz, S. A., Anwander, A., Axer, H., & Knösche, T. R. (2013). Beyond cytoarchitectonics: The internal and external connectivity structure of the caudate nucleus. PLoS One, 8(7): e70141. doi:10.1371/journal.pone.0070141.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-AA41-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-858B-A
Genre: Journal Article

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 Creators:
Kotz, Sonja A.1, 2, Author              
Anwander, Alfred1, Author              
Axer, Hubertus3, Author
Knösche, Thomas R.4, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2School of Psychological Sciences, University of Manchester, United Kingdom, ou_persistent22              
3Hans Berger Clinic for Neurology, Jena University Hospital, Germany, ou_persistent22              
4Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              

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 Abstract: While there is ample evidence on the functional and connectional differentiation of the caudate nucleus (CN), less is known about its potential microstructural subdivisions. However, this latter aspect is critical to the local information processing capabilities of the tissue. We applied diffusion MRI, a non-invasive in vivo method that has great potential for the exploration of the brain structure-behavior relationship, in order to characterize the local fiber structure in gray matter of the CN. We report novel evidence of a functionally meaningful structural tri-partition along the anterior-posterior axis of this region. The connectivity of the CN subregions is in line with connectivity evidence from earlier invasive studies in animal models. In addition, histological validation using polarized light imaging (PLI) confirms these results, corroborating the notion that cortico-subcortico-cortical loops involve microstructurally differentiated regions in the caudate nucleus. Methodologically speaking, the comparison with advanced analysis of diffusion MRI shows that diffusion tensor imaging (DTI) yields a simplified view of the CN fiber architecture which is refined by advanced high angular resolution imaging methods.

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Language(s): eng - English
 Dates: 2013-03-032013-06-142013-07-26
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0070141
PMID: 23922939
PMC: PMC3724823
Other: Print 2013
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 8 (7) Sequence Number: e70141 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: /journals/resource/1000000000277850