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  Regional effects of magnetization dispersion on quantitative perfusion imaging for pulsed and continuous arterial spin labeling

Cavusoglu, M., Pohmann, R., Burger, H., & Uludag, K. (2013). Regional effects of magnetization dispersion on quantitative perfusion imaging for pulsed and continuous arterial spin labeling. Magnetic Resonance in Medicine, 69(2), 524-530. doi:10.1002/mrm.24278.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B504-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-484D-9
Genre: Journal Article

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Cavusoglu, M1, 2, Author              
Pohmann, R1, 2, Author              
Burger, HC2, 3, Author              
Uludag, K, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              

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 Abstract: Most experiments assume a global transit delay time with blood flowing from the tagging region to the imaging slice in plug flow without any dispersion of the magnetization. However, because of cardiac pulsation, nonuniform cross-sectional flow profile, and complex vessel networks, the transit delay time is not a single value but follows a distribution. In this study, we explored the regional effects of magnetization dispersion on quantitative perfusion imaging for varying transit times within a very large interval from the direct comparison of pulsed, pseudo-continuous, and dual-coil continuous arterial spin labeling encoding schemes. Longer distances between tagging and imaging region typically used for continuous tagging schemes enhance the regional bias on the quantitative cerebral blood flow measurement causing an underestimation up to 37 when plug flow is assumed as in the standard model.

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 Dates: 2013-02
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.24278
BibTex Citekey: CavusogluPBU2012
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 69 (2) Sequence Number: - Start / End Page: 524 - 530 Identifier: -