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  Multifunctional silica nanoparticles for optical and magnetic resonance imaging

Joshi, R., Feldman, V., Koestner, W., Detje, C., Gottschalk, S., Mayer, H., et al. (2013). Multifunctional silica nanoparticles for optical and magnetic resonance imaging. Biological Chemistry, 394(1), 125-135. doi:10.1515/hsz-2012-0251.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B51E-F Version Permalink: http://hdl.handle.net/21.11116/0000-0001-487B-5
Genre: Journal Article

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 Creators:
Joshi, R1, 2, Author              
Feldman, V, Author
Koestner, W, Author
Detje, C, Author
Gottschalk, S1, 2, Author              
Mayer, HA, Author
Sauer, MG, Author
Engelmann, J1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9–16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×105 and ~5×105 /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.

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 Dates: 2013-01
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: JoshiFKDGMSE2013
DOI: 10.1515/hsz-2012-0251
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Title: Biological Chemistry
Source Genre: Journal
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Pages: - Volume / Issue: 394 (1) Sequence Number: - Start / End Page: 125 - 135 Identifier: -