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  High-Resolution fMRI Reveals Laminar Differences in Neurovascular Coupling between Positive and Negative BOLD Responses

Goense, J., Merkle, H., & Logothetis, N. (2012). High-Resolution fMRI Reveals Laminar Differences in Neurovascular Coupling between Positive and Negative BOLD Responses. Neuron, 76(3), 629-639. doi:10.1016/j.neuron.2012.09.019.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B55C-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-8457-8
Genre: Journal Article

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Goense, J1, 2, Author              
Merkle, H, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The six cortical layers have distinct anatomical and physiological properties, like different energy use and different feedforward and feedback connectivity. It is not known if and how layer-specific neural processes are reflected in the fMRI signal. To address this question we used high-resolution fMRI to measure BOLD, CBV, and CBF responses to stimuli that elicit positive and negative BOLD signals in macaque primary visual cortex. We found that regions with positive BOLD responses had parallel increases in CBV and CBF, whereas areas with negative BOLD responses showed a decrease in CBF but an increase in CBV. For positive BOLD responses, CBF and CBV increased in the center of the cortex, but for negative BOLD responses, CBF decreased superficially while CBV increased in the center. Our findings suggest different mechanisms for neurovascular coupling for BOLD increases and decreases, as well as laminar differences in neurovascular coupling.

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 Dates: 2012-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neuron.2012.09.019
BibTex Citekey: GoenseML2012_2
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 76 (3) Sequence Number: - Start / End Page: 629 - 639 Identifier: -