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  Hippocampal-cortical interaction during periods of subcortical silence

Logothetis, N., Eschenko, O., Murayama, Y., Augath, M., Steudel, T., Evrard, H., et al. (2012). Hippocampal-cortical interaction during periods of subcortical silence. Nature, 491(7425), 547-553. doi:10.1038/nature11618.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B55E-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1C06-A
Genre: Journal Article

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Logothetis, NK1, 2, Author              
Eschenko, O1, 2, Author              
Murayama, Y1, 2, Author              
Augath, M1, 2, Author              
Steudel, T1, 2, Author              
Evrard, HC1, 2, Author              
Besserve, M1, 2, 3, Author              
Oeltermann, A1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Dept. Empirical Inference, Max Planck Institute for Intelligent System, Max Planck Society, ou_1497647              

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 Abstract: Hippocampal ripples, episodic high-frequency field-potential oscillations primarily occurring during sleep and calmness, have been described in mice, rats, rabbits, monkeys and humans, and so far they have been associated with retention of previously acquired awake experience. Although hippocampal ripples have been studied in detail using neurophysiological methods, the global effects of ripples on the entire brain remain elusive, primarily owing to a lack of methodologies permitting concurrent hippocampal recordings and whole-brain activity mapping. By combining electrophysiological recordings in hippocampus with ripple-triggered functional magnetic resonance imaging, here we show that most of the cerebral cortex is selectively activated during the ripples, whereas most diencephalic, midbrain and brainstem regions are strongly and consistently inhibited. Analysis of regional temporal response patterns indicates that thalamic activity suppression precedes the hippocampal population burst, which itself is temporally bounded by massive activations of association and primary cortical areas. These findings suggest that during off-line memory consolidation, synergistic thalamocortical activity may be orchestrating a privileged interaction state between hippocampus and cortex by silencing the output of subcortical centres involved in sensory processing or potentially mediating procedural learning. Such a mechanism would cause minimal interference, enabling consolidation of hippocampus-dependent memory.

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 Dates: 2012-11
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/nature11618
BibTex Citekey: LogothetisEMASEBO2012
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Title: Nature
Source Genre: Journal
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Pages: - Volume / Issue: 491 (7425) Sequence Number: - Start / End Page: 547 - 553 Identifier: -