English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The role of adenosine in the neurovascular coupling of the BOLD signal in early visual cortex of non-human primates

Viswanath, S., Zaldivar, D., von Pföstl, V., Rauch, A., & Logothetis, N. (2012). The role of adenosine in the neurovascular coupling of the BOLD signal in early visual cortex of non-human primates. Poster presented at 13th Conference of the Junior Neuroscientists of Tübingen (NeNA 2012): Science and Education as Social Transforming Agents, Schramberg, Germany.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B576-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-9A56-1
Genre: Poster

Files

show Files

Creators

show
hide
 Creators:
Viswanath, S1, 2, Author              
Zaldivar, D1, 2, Author              
von Pföstl, V1, 2, Author              
Rauch, A1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: In this study, CPX, an antagonist of adenosine was used to determine the role of adenosine in uncoupling the vascular and neuronal response observed by the BOLD signal after a strong visual stimulation in primary visual cortex (V1). We systemically and locally applied CPX and pharmacologically manipulated the sensory response in the early visual cortex of anaesthetized macaques. Pharmacological magnetic resonance imaging (phMRI) in combination with electrophysiology was used to determine the impact of CPX on V1. Results were obtained from recordings of the BOLD and electrophysiological activity during the injections. Systemic application of CPX resulted in a disruption of the visual modulation in the BOLD signal. Local applications of CPX resulted in a decrease in the power of low LFP and an increase in the power of MUA. In addition it resulted in a decrease in the CV and FF. No significant changes were observed in the BOLD signal after systemic application of phosphate buffered saline, which was used as a control. The results show that we indeed observe dissociation between the vascular and the neuronal activity during adenosinergic modulation. Apparently adenosine reduces functional hyperaemia, which is reflected by the reduction in BOLD signal, while underlying neuronal activity is increased, indicated by an increase in MUA. Further studies have to be conducted using simultaneous sampling of neurochemicals and phMRI to fully elucidate the functional role of adenosine for the vascular and neuronal interplay in V1.

Details

show
hide
Language(s):
 Dates: 2012-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: ViswanathZvRL2012
 Degree: -

Event

show
hide
Title: 13th Conference of the Junior Neuroscientists of Tübingen (NeNA 2012): Science and Education as Social Transforming Agents
Place of Event: Schramberg, Germany
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: 13th Conference of the Junior Neuroscientists of Tübingen (NeNA 2012): Science and Education as Social Transforming Agents
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 48 Identifier: -