English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Longitudinal fMRI study of cortical development in young monkeys

van Grootel, T., Meeson, A., Munk, M., Kourtzi, Z., Movshon, J., Logothetis, N., et al. (2012). Longitudinal fMRI study of cortical development in young monkeys. Poster presented at 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012), New Orleans, LA, USA.

Item is

Files

show Files

Creators

show
hide
 Creators:
van Grootel, TJ1, 2, Author              
Meeson, A, Author
Munk, M1, 2, Author              
Kourtzi, Z, Author              
Movshon, JA, Author
Logothetis, NK1, 2, Author              
Kiorpes, L, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: In typical adult visual processing, low-level visual features are integrated into a global construct that enables the recognition of an object. Behaviorally, young primates are impaired at integrating global form and motion cues. Also the neural machinery to support global processing is not fully developed. However, earlier studies using single-unit electrophysiology show that neuronal response properties are relatively mature compared to behavioral capability. Behavioral sensitivity to global stimuli continues to improve for months or years beyond the time that neuronal responses are adult-like. To understand this discrepancy, we used a larger scale method to investigate cortical development, functional MRI. We tracked the development of BOLD activation in striate and extra-striate cortex of macaque monkeys (Macaca mulatta) longitudinally over 2-3 years. The animals were imaged at 4.7T while anesthetized and paralyzed. To segregate dorsal and ventral stream activity, we used stationary and dynamic Glass pattern stimuli. These have comparable local features (dipoles) but different global forms (concentric or radial) and responses were compared to random-dipole patterns having the same overall statistics. We analyzed responses to a variety of spatial and spatio-temporal stimuli using multi-voxel pattern analysis (MVPA). We determined how classification accuracy depended on the cumulative number of voxels from different cortical areas using a support vector machine (SVM). In young monkeys (age < 2 years), we observed high classification accuracies in primary visual cortex (V1) when Glass patterns were present or absent (stimulus vs. blank) but lower accuracy for static vs. dynamic patterns. Only 2/10 imaging sessions yielded accuracies significantly higher than chance for the same contrast in extrastriate area MT of young monkeys. These same comparisons consistently produced high classification accuracy in animals older than 2 years. These results indicate that BOLD signal differences can be measured at young ages with a Glass pattern stimulus. However, signals related to pattern type are not distinguished reliably until older ages. These results complement our earlier findings showing late onset of activation patterns in extrastriate cortex (Kourtzi et al., 2006, Mag Res Imaging).

Details

show
hide
Language(s):
 Dates: 2012-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: URI: http://www.sfn.org/am2012/
BibTex Citekey: vanGrootelMMKMLK2012
 Degree: -

Event

show
hide
Title: 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012)
Place of Event: New Orleans, LA, USA
Start-/End Date: -

Legal Case

show

Project information

show

Source 1

show
hide
Title: 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: 464.14 Start / End Page: - Identifier: -