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  A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes

Keliris, A., Mamedov, I., Hagberg, G., Logothetis, N., Scheffler, K., & Engelmann, J. (2012). A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes. Contrast Media and Molecular Imaging, 7(5), 478-483. doi:10.1002/cmmi.1470.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B612-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-84D0-E
Genre: Journal Article

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 Creators:
Keliris, A1, 2, Author              
Mamedov, I2, 3, Author              
Hagberg, GE1, 2, 3, Author              
Logothetis, NK2, 3, Author              
Scheffler, K1, 2, Author              
Engelmann, J1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Here we report on a dual-modal 19F and 1H MRI paramagnetic probe with a self-immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by β-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd3+ complex to modulate the 1H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by 19F and 1H MRI using this molecular design is proposed.

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 Dates: 2012-09
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/cmmi.1470
BibTex Citekey: KelirisMHLSE2012
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Title: Contrast Media and Molecular Imaging
Source Genre: Journal
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Pages: - Volume / Issue: 7 (5) Sequence Number: - Start / End Page: 478 - 483 Identifier: -