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  Detailed functional and structural characterization of a macular lesion in a rhesus macaque

Fischer, M., Zobor, D., Keliris, G., Shao, Y., Seeliger, M., Haverkamp, S., et al. (2012). Detailed functional and structural characterization of a macular lesion in a rhesus macaque. Documenta Ophthalmologica, 125(3), 179-194. doi:10.1007/s10633-012-9340-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B66C-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-95C2-8
Genre: Journal Article

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 Creators:
Fischer, MD, Author
Zobor, D, Author
Keliris, GA1, 2, Author              
Shao, Y1, 2, Author              
Seeliger, MW, Author
Haverkamp, S, Author
Jägle, H, Author
Logothetis, NK1, 2, Author              
Smirnakis, SM1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Animal models are powerful tools to broaden our understanding in disease mechanisms and to develop future treatment strategies. Here we present detailed structural and functional findings of a rhesus macaque suffering from a naturally occurring bilateral macular dystrophy (BMD), partial optic atrophy and corresponding reduction of central V1 signals in visual fMRI experiments when compared to data in a healthy macaque (CTRL) of similar age. Fluorescence and indocyanine green angiography showed reduced macular vascularization with significantly larger foveal avascular zones (FAZ) in the affected animal (FAZBMD = 8.85 mm2 vs. FAZCTRL = 0.32 mm2). Optical coherence tomography showed bilateral thinning of the macula within the FAZ (total retinal thickness, TRTBMD = 174 ± 9 μm) and partial optic nerve atrophy when compared to control (TRTCTRL = 303 ± 45 μm). Segmentation analysis revealed that inner retinal layers were primarily affected (inner retinal thickness, IRTBMD = 33 ± 9 μm vs. IRTCTRL = 143 ± 45 μm), while the outer retina essentially maintained its thickness (ORTBMD = 141 ± 7 μm vs. ORTCTRL = 160 ± 11 μm). Accordingly, a strong central reduction in the multifocal electroretinography and a specific attenuation of cone-derived signals in Ganzfeld electroretinography was found, whereas rod function remained normal. We provided detailed characterization of a primate macular disorder. This study aims to stimulate awareness and further investigation in primates with macular disorders eventually leading to the identification of a primate animal model and facilitating the preclinical development of therapeutic strategies.

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 Dates: 2012-08
 Publication Status: Published in print
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 Identifiers: DOI: 10.1007/s10633-012-9340-3
BibTex Citekey: FischerZKSSJLS2012
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Title: Documenta Ophthalmologica
Source Genre: Journal
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Pages: - Volume / Issue: 125 (3) Sequence Number: - Start / End Page: 179 - 194 Identifier: -