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  Population receptive field measurements in macaque visual cortex

Smirnakis, S., Keliris, G., Shao, Y., Papanikolaou, A., & Logothetis, N. (2012). Population receptive field measurements in macaque visual cortex. Poster presented at 12th Annual Meeting of the Vision Sciences Society (VSS 2012), Naples, FL, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B698-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-BDD7-5
Genre: Poster

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 Creators:
Smirnakis, SM, Author              
Keliris, GA1, 2, Author              
Shao, Y1, 2, Author              
Papanikolaou, A1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Visual receptive fields have dynamic properties that may change with the conditions of visual stimulation or with the state of chronic visual deprivation. We used 4.7 Tesla functional magnetic resonance imaging (fMRI) to study the visual cortex of two normal adult macaque monkeys and one macaque with binocular central retinal lesions due to a form of juvenile macular degeneration (MD). FMRI experiments were performed under light remifentanyl induced anesthesia (Logothetis et al. Nat. Neurosci. 1999). Standard moving horizontal/vertical bar stimuli were presented to the subjects and the population receptive field (pRF) method (Dumoulin and Wandell, Neuroimage 2008) was used to measure retinotopic maps and pRF sizes in early visual areas. FMRI measurements of normal monkeys agree with published electrophysiological results, with pRF sizes and electrophysiology measurements showing similar trends. For the MD monkey, the size and location of the lesion projection zone (LPZ) was consistent with the retinotopic projection of the retinal lesion in early visual areas. No significant BOLD activity was seen within the V1 LPZ, and the retinotopic organization of the non-deafferented V1 periphery was regular without distortion. Interestingly, area V5/MT of the MD monkey showed more extensive activation than area V5/MT of control monkeys which had part of their visual field obscured (artificial scotoma) to match the scotoma of the MD monkey. V5/MT PRF sizes of the MD monkey were on average smaller than controls. PRF estimation methods allow us to measure and follow in vivo how the properties of visual areas change as a function of cortical reorganization. Finally, if there is time, we will discuss a different method of pRF estimation that yields additional information.

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 Dates: 2012-08
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: SmirnakisKSPL2012
DOI: 10.1167/12.9.1397
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Title: 12th Annual Meeting of the Vision Sciences Society (VSS 2012)
Place of Event: Naples, FL, USA
Start-/End Date: 2012-05-11 - 2012-05-16

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Title: Journal of Vision
Source Genre: Journal
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Publ. Info: Charlottesville, VA : Scholar One, Inc.
Pages: - Volume / Issue: 12 (9) Sequence Number: - Start / End Page: 1397 Identifier: ISSN: 1534-7362
CoNE: https://pure.mpg.de/cone/journals/resource/111061245811050