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Zusammenfassung:
Using resting state fMRI (rsfMRI), the „dorsal nexus“ (DN) was recently identified as a dorsomedial prefrontal cortex region showing increased depression-associated fMRI connectivity with portions of the cognitive control (CCN), the default mode (DMN), and the affective (AN) network. In this double-blind, randomized, placebo-controlled, crossover study we report decreased connectivity of the sgACC (AN) and PCC (DMN) via the DN 24 hours following the administration of an antidepressant dose of ketamine. We conclude that reducing the hyperconnectivity via the DN may play a critical role in reducing depressive symptomatology and thus represent a systems level mechanism of antidepressant treatment response.
