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  Development of multimodal imaging probes for neuroanatomical connectivity studies in vivo by means of MRI

Mamedov, I., Engelmann, J., Hagberg, G., Eschenko, O., & Logothetis, N. (2012). Development of multimodal imaging probes for neuroanatomical connectivity studies in vivo by means of MRI. Poster presented at 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B796-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-A54A-2
Genre: Poster

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 Creators:
Mamedov, I1, 2, Author              
Engelmann, J2, 3, Author              
Hagberg, G1, 2, Author              
Eschenko, O1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: A Gd3+ based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies demonstrated that the synthesized tracer was efficiently internalized into neuronal cells and transported toward the axons. Furthermore, our preliminary in vivo experiments revealed efficient transportation of the conjugate, thereby proving its applicability for neuroanatomical studies by T1-weighted MRI. Initial in vivo experiments in rodents demonstrated the significant potential of this method.

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 Dates: 2012-05
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: MamedovEHEL2012
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Title: 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012)
Place of Event: Melbourne, Australia
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Title: 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1632 Start / End Page: - Identifier: -