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  Synthesis and in Vitro Evaluation of a Biotinylated Dextran-Derived Probe for Molecular Imaging

Mishra, A., Joshi, R., Engelmann, J., & Logothetis, N. (2012). Synthesis and in Vitro Evaluation of a Biotinylated Dextran-Derived Probe for Molecular Imaging. ACS Chemical Neuroscience, 3(4), 268-273. doi:10.1021/cn200112v.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B7DE-F Version Permalink: http://hdl.handle.net/21.11116/0000-0001-886C-D
Genre: Journal Article

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http://pubs.acs.org/doi/pdf/10.1021/cn200112v (Publisher version)
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 Creators:
Mishra, A1, 2, Author              
Joshi, R2, 3, Author              
Engelmann, J2, 3, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Herein we report the design, synthesis, and in vitro evaluation of a gadolinium-containing biotinylated dextran-derived molecular imaging probe as a prospective neuroanatomical tracer by means of magnetic resonance imaging (MRI). The probe was effectively taken up by cultured differentiated murine neuroblastoma cells and significantly enhanced the contrast in T1- and T2-weighted MR images of labeled cells under physiological conditions. A significant longitudinal relaxation rate enhancement in the presence of avidin was observed allowing the verification of the results in the end of noninvasive longitudinal MRI connectivity studies by post-mortem histology. The in vitro results indicate that the probe has the potential to be used in vivo to identify the organization of global neuronal networks in the brain with MRI.

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 Dates: 2012-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/cn200112v
BibTex Citekey: MishraJEL2012
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Title: ACS Chemical Neuroscience
Source Genre: Journal
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Pages: - Volume / Issue: 3 (4) Sequence Number: - Start / End Page: 268 - 273 Identifier: -