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  Functional imaging in freely moving animals

Kerr, J., & Nimmerjahn, A. (2012). Functional imaging in freely moving animals. Current Opinion in Neurobiology, 22(1), 45-53. doi:10.1016/j.conb.2011.12.002.

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Kerr, JND1, 2, 3, Autor           
Nimmerjahn, A, Autor
Affiliations:
1Former Research Group Network Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528697              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Research Group Neural Population Imaging, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497807              

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 Zusammenfassung: Uncovering the relationships between animal behavior and cellular activity in the brain has been one of the key aims of neuroscience research for decades, and still remains so. Electrophysiological approaches have enabled sparse sampling from electrically excitable cells in freely moving animals that has led to the identification of important phenomena such as place, grid and head-direction cells. Optical imaging in combination with newly developed labeling approaches now allows minimally invasive and comprehensive sampling from dense networks of electrically and chemically excitable cells such as neurons and glia during self-determined behavior. To achieve this two main imaging avenues have been followed: Optical recordings in head-restrained, mobile animals and miniature microscope-bearing freely moving animals. Here we review progress made toward functional cellular imaging in freely moving rodents, focusing on developments over the past few years. We discuss related challenges and biological applications.

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 Datum: 2012-02
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1016/j.conb.2011.12.002
BibTex Citekey: KerrN2012
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Titel: Current Opinion in Neurobiology
  Andere : Curr. Opin.Neurobiol.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, NY : Elsevier Current Trends
Seiten: - Band / Heft: 22 (1) Artikelnummer: - Start- / Endseite: 45 - 53 Identifikator: ISSN: 0959-4388
CoNE: https://pure.mpg.de/cone/journals/resource/954925578066