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  Biocytin-based contrast agents for molecular imaging: an approach to developing new in vivo neuroanatomical tracers for MRI

Mishra, A., Mishra, R., Canals, S., Logothetis, N., Beyerlein, M., Engelmann, J., et al. (2012). Biocytin-based contrast agents for molecular imaging: an approach to developing new in vivo neuroanatomical tracers for MRI. In P. Bright (Ed.), Neuroimaging - Methods (pp. 181-204). Rijeka, Croatia: InTech.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-B840-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-97B0-D
Genre: Book Chapter

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 Creators:
Mishra, A1, 2, Author              
Mishra, R2, 3, Author              
Canals, S1, 2, Author              
Logothetis, NK1, 2, Author              
Beyerlein, M1, 2, Author              
Engelmann, J2, 3, Author              
Schüz, A1, 2, Author              
Dhingra, K1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: One of the most striking characteristic of the brain is its profuse neuronal connectivity. Not surprisingly, the function of the nervous system critically depends on the spatiotemporal pattern of intercommunication between different regions of the brain. Both macro- and microscopic aspects of the wiring diagrams of brain circuits are relevant and need to be understood in order to cope with the complexity of the brain function. In this way, for instance, the long-range connections that carry the functional specification of cortical territories need to be studied together with the detailed microcircuits inside a cortical column. Moreover, the temporal dimension of these wiring diagrams must be investigated since neuronal networks are dynamic structures exhibiting context-dependent changes in synaptic weights (Canals et al., 2009) and numbers (Chklovskii et al., 2004). Investigations over the last decades strongly suggest that stimulus or task related neural activity is distributed over large parts of the brain, covering different cortical and sub-cortical areas. For a detailed understanding of brain function, it is of prime importance to understand the organization of the neuronal connections. To chart the anatomical connections between the various components of brain networks, the neuronal tract tracing technique has been proved to be very useful. Thus, experimental tools that allow the exploration of brain circuits at diverse organizational levels are mandatory for the understanding of brain intercommunication and information processing.

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 Dates: 2012-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.5772/23806
BibTex Citekey: MishraDMSEBCL2011
 Degree: -

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Title: Neuroimaging - Methods
Source Genre: Book
 Creator(s):
Bright, P, Editor
Affiliations:
-
Publ. Info: Rijeka, Croatia : InTech
Pages: - Volume / Issue: 1 Sequence Number: 9 Start / End Page: 181 - 204 Identifier: ISBN: 978-953-51-0097-3